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目的分析原发性干燥综合征(PSS)继发间质性肺病(ILD)的临床特点。方法回顾性分析214例PSS患者的临床资料。其中,86例继发ILD(ILD组),128例无ILD(无ILD组);比较两组的临床特点。结果与无ILD组相比,ILD组发病年龄大、病程长(P<0.05),呼吸困难、口干、眼干、猖獗齿、发热、雷诺现象、关节炎、肾脏及神经系统损害发生率高(P<0.05),血沉、C-反应蛋白、类风湿因子、免疫球蛋白G(IgG)、IgA、纤维蛋白原、乳酸脱氢酶水平和抗核抗体、抗干燥综合征A抗体和抗心磷脂抗体阳性率高,补体C3、白蛋白水平低(P<0.05)。结论年龄较大和病程较长的PSS患者易发生ILD,相关实验室指标发生改变,系统损害明显。
Objective To analyze the clinical features of interstitial lung disease (ILD) secondary to Sjogren’s syndrome (PSS). Methods The clinical data of 214 PSS patients were retrospectively analyzed. Among them, 86 cases of secondary ILD (ILD group), 128 cases of no ILD (no ILD group); the clinical features of the two groups were compared. Results Compared with no ILD group, the ILD group was older and had a longer course of disease (P <0.05). The incidence of dyspnea, dry mouth, dry eyes, rampant teeth, fever, Raynaud’s phenomenon, arthritis, renal and nervous system injury were high (P <0.05), ESR, C-reactive protein, rheumatoid factor, immunoglobulin G (IgG), IgA, fibrinogen, lactate dehydrogenase levels and antinuclear antibodies, anti-Sjogren’s syndrome A antibodies and anti- The positive rate of phospholipid antibodies, complement C3, albumin levels were low (P <0.05). CONCLUSIONS: Patients with older and longer duration of PSS are prone to develop ILD and the relevant laboratory indicators change, with obvious systemic damage.