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目的:研究畸胎瘤细胞源性生长因子(PCc ell-derived growth factor,PCDGF)的表达与乳腺癌血管形成的关系及其临床意义。方法:采用免疫组织化学的方法对130例乳腺手术标本中的PCDGF及其中70例乳腺癌组织中的血管内皮因子(vascular endothelial growth factor,VEGF)、微血管密度(mean microvessel density,MVD)的表达情况进行检测。结果:乳腺癌中PCDGF的表达显著高于非乳腺癌组织(P<0.05)。乳腺癌中PCDGF阳性组MVD水平明显高于阴性组(P<0.01),VEGF阳性组MVD水平明显高于阴性组(P<0.01),二者表达呈正相关(P<0.05)。结论:PCDGF在乳腺癌中特异性表达,调节协同VEGF调控乳腺癌血管形成,有望作为乳腺癌早期诊断指标和抗血管治疗的新靶点。
Objective: To study the relationship between the expression of PCD-derived growth factor (PCDGF) and angiogenesis in breast cancer and its clinical significance. Methods: Immunohistochemistry was used to detect the expression of PCDGF in 130 breast cancer specimens and the expression of vascular endothelial growth factor (VEGF) and microvessel density (MVD) in 70 breast cancer tissues. Test. Results: The expression of PCDGF in breast cancer was significantly higher than that in non-breast cancer (P <0.05). The MVD level in PCDGF positive group was significantly higher than that in negative group (P <0.01). The MVD level in VEGF positive group was significantly higher than that in negative group (P <0.01). The expression of MVD was positively correlated (P <0.05). CONCLUSION: PCDGF is specifically expressed in breast cancer. Regulating the synergistic effect of VEGF in the regulation of angiogenesis in breast cancer may serve as a new target for early diagnosis of breast cancer and an anti-angiogenic therapy.