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目的探讨克拉霉素预防呼吸机相关性肺炎(VAP)的疗效。方法随机选择2009年1月—2012年3月焦煤集团中央医院呼吸科呼吸急危重病需要机械通气的成年患者206例,采用随机、单盲方法对该206例患者进行试验分组,其中试验组103例患者,对照组103例患者,对照组患者采用常规治疗,而试验组患者在常规治疗的基础上鼻饲克拉霉素0.5g,1次/d。观察并记录VAP发生率,平均机械通气时间和平均住ICU时间。结果试验组和对照组患者中VAP的发生率分别为32%和61%(P<0.05)。试验组平均机械通气时间、平均住ICU时间较对照组明显缩短(P<0.05)。结论克拉霉素鼻饲可显著降低VAP的发生率,缩短机械通气时间和平均住ICU时间。
Objective To investigate the effect of clarithromycin in preventing ventilator associated pneumonia (VAP). Methods A total of 206 adult patients with respiratory emergency respiratory diseases requiring mechanical ventilation were randomly selected from Central Hospital of Coking Coal from January 2009 to March 2012. The 206 patients were randomly divided into two groups. The patients, the control group of 103 patients, the control group of patients treated with conventional therapy, while the experimental group of patients on the basis of conventional treatment of nasal feeding clarithromycin 0.5g, 1 / d. The incidence of VAP, mean duration of mechanical ventilation and average ICU stay were observed and recorded. Results The incidence of VAP in the trial and control groups was 32% and 61%, respectively (P <0.05). The mean mechanical ventilation time and mean ICU stay in test group were significantly shorter than those in control group (P <0.05). Conclusion Clarithromycin nasal feeding can significantly reduce the incidence of VAP, shorten the duration of mechanical ventilation and ICU live on average.