热休克蛋白gp96(HSPgp96)是一种高度保守和呈单态性的蛋白质。它能与细胞内大量多肽非共价结合 ,参与MHCⅠ类抗原的提呈。用肿瘤源HSPgp96 肽复合物免疫小鼠可诱发抗相应肿瘤细胞的MHCⅠ类限制性CD8+ 细胞毒性T细胞免疫应答 ,并能产生记忆性T细胞应答 ,具备了作为疫苗的一个关键要素 ,为肿瘤免疫治疗开辟了一个新的途径。本文对HSPgp96与肾癌免疫治疗的研究作一概述。 Heat shock protein gp96 (HSPgp96) is a highly conserved and monomeric protein. It can non-covalently bind to a large number of intracellular peptides and participate in the presentation of MHC class I antigens. Immunization of mice with the tumor-derived HSPgp96 peptide complex induced MHC class I-restricted CD8 + cytotoxic T cell immune responses against corresponding tumor cells and produced a memory T cell response with a key element of the vaccine for tumor immunity Treatment opened up a new avenue. This article summarizes the study of HSPgp96 and renal cell carcinoma immunotherapy.