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目的 探讨腹腔渗液肿瘤相关抗原MGAgs与胃癌病理学及生物学行为的关系。方法 对32例胃癌病人外周血清及术中腹腔渗液中肿瘤相关抗原MGAgs检测,并与胃癌病理变化进行对比研究。结果 腹腔渗液中MGAgs升高与肿瘤浸润程度,有否腹腔淋巴结转移等有显著性差异,腹膜播散时MGAgs升高更为明显。结论 腹腔渗液中MGAgs主要由肿瘤细胞直接分泌到腹腔,测定腹腔渗液MGAgs对预测胃癌腹腔转移复发具有一定的参考价值。
Objective To investigate the relationship between peritoneal effusion tumor-associated antigen MGAgs and the pathological and biological behaviors of gastric cancer. Methods To detect the tumor-associated antigen MGAgs in peripheral blood and intraoperative abdominal fluid in 32 patients with gastric cancer, and to compare the pathological changes of gastric cancer. Results There were significant differences in the elevation of MGAgs, tumor invasion, and lymph node metastasis in the peritoneal exudate. The MGAgs elevation was more evident in the peritoneal dissemination. Conclusion The MGAgs in the peritoneal exudates are secreted directly from the tumor cells into the abdominal cavity. The measurement of peritoneal effusions of MGAgs has certain reference value in predicting the metastasis and recurrence of gastric cancer.