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目的探讨Borna病病毒(BDV)感染与人类病毒性脑炎的关系。方法采用荧光定量套式逆转录酶聚合酶链反应(FQ nRT PCR)检测了59例临床诊断的原因未明的病毒性脑炎及112名健康人外周血单个核细胞(PBMC)中BDVP24基因片段。结果59例原因未明的病毒性脑炎患者中有3例PBMC中检出BDVP24基因片段,而112名健康对照均未检出。病毒性脑炎患者BDV阳性率(5.08%)高于健康对照,差异有统计学意义(P<0.05),且BDVP24基因片段检测阳性病例的脑脊液中其他常见致脑炎病毒(单纯疱疹病毒、带状疱疹病毒、腮腺炎病毒、柯萨奇病毒和巨细胞病毒)检查均为阴性。结论中国的部分病毒性脑炎患者中存在BDV感染,BDV感染与病毒性脑炎的发病可能有关。
Objective To investigate the relationship between Borna disease virus (BDV) infection and human viral encephalitis. Methods FQ nRT PCR was used to detect 59 cases of viral encephalitis of unknown etiology and 112 cases of BDVP24 gene in peripheral blood mononuclear cells (PBMCs) of healthy people. Results The BDVP24 gene fragment was detected in PBMC of 59 cases of unexplained viral encephalitis, but none of the 112 healthy controls were detected. The positive rate of BDV in patients with viral encephalitis (5.08%) was higher than that in healthy controls (P <0.05), and other common encephalitis viruses (herpes simplex virus Herpes zoster virus, mumps virus, Coxsackie virus and cytomegalovirus) were negative. Conclusion BDV infection exists in some patients with viral encephalitis in China. BDV infection may be related to the pathogenesis of viral encephalitis.