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采用放射免疫测定法对６２例正常新生儿和６３冽高胆红素血症新生儿进行尿ａ_１－Ｍ含量测定，以探讨高胆红素血症（简称高胆）对新生儿肾小管功能的影响，结果表明：（１）生理性黄疽对新生儿肾小管功能无明显影响；（２）高胆对新生儿肾小管功能的损害与血胆红素浓搜密切相关，严重高胆对肾小管功能影响较大；（３）高胆对肾小管功能的损害最早可于发病２４～４８ｈ发生，而以２～７ｄ最为明显，因而测定尿ａ_１－Ｍ对高胆引起的肾小管损害具有早期诊断价值；（４）动态观察表明：高胆对肾小管功能的损害是可逆性的，多数恢复较好。尿ａ_１－Ｍ亦可作为反映肾小管功能恢复的敏感指标，但对高胆所致肾小管功能损害的预后判断尚需进一步观察证实。
Radioimmunoassay 62 cases of normal newborns and 63 冽 hyperbilirubinemia urine a_1-M content determination of urine to explore the hyperbilirubinemia (hyperbilirubinemia) of neonatal renal tubular function (1) Physiological jaundice had no significant effect on the function of renal tubules in neonates; (2) The damage of renal tubules by high bile was closely related to the concentration of bilirubin, (3) The injury of renal tubular function by high bile can occur as early as 24-48 h, but most obviously by 2-7 d, so the urinary a 1-M can be used to detect the early damage of renal tubular induced by high bile Diagnostic value; (4) Dynamic observation shows that: high bile damage to renal tubular function is reversible, most of the recovery is better. Urine a_1-M can also be used as a sensitive indicator of renal tubular function recovery, but the prognosis of renal tubular dysfunction caused by high bile need to be further confirmed.