神经元包涵体包含泛素阳性蛋白聚集体是许多人类神经变性疾病(包括阿尔茨海默病、肌萎缩性侧索硬化、多谷氨酸聚合病等)的一种常见特征。是这些蛋白的聚集导致神经元异常,还是它们的聚集本身无害甚至有益,亦或仅仅是发病所致的继发性产物。过去的几年里,在神经发育和神经变性疾 Neuronal inclusion bodies containing ubiquitin-positive protein aggregates are a common feature of many human neurodegenerative diseases, including Alzheimer’s disease, amyotrophic lateral sclerosis, polyglutamate disorders, and the like. Whether the aggregation of these proteins leads to abnormalities in the neurons, or their aggregation is not harmful or even beneficial, or just a secondary cause of the disease. In the past few years, neurodevelopment and neurodegenerative diseases