环腺苷二磷酸核糖（ｃＡＤＰＲ）是一种重要的核苷酸衍生物，最近广泛地研究报道ｃＡＤＰＲ是Ｃａ２＋释放的激活剂。本文对ｃＡＤＰＲ的重要中间体肌苷的碱基Ｎ１－位糖基化衍生物进行了基质辅助激光解吸飞行时间质谱测定，证明了所合成核苷化合物的正确性，相对误差小于０．１％ Cyclic adenosine diphosphate ribose (cADPR) is an important nucleotide derivative, and cADPR has recently been widely reported to be an activator of Ca2 + release. In this paper, matrix-assisted laser desorption time-of-flight mass spectrometry was performed on the base N1-glycosylated derivatives of the important intermediate inosine of cADPR, and the correctness of the synthesized nucleoside compounds was proved. The relative error was less than 0.1%