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为探讨Ｎｏｒｐｌａｎｔ埋植后不规则出血的内膜与性激素受体的相关性，对正常月经周期和Ｎｏｒｐｌａｎｔ埋植６个月、１年有不规则出血的人子宫内膜进行形态学与免疫组织化学ＥＲ和ＰＲ的观察。结果证明不规则子宫出血的内膜无典型周期性变化；部分内膜血管断裂，雌激素受体（ＥＲ）和孕激素受体（ＰＲ）有不同程度的减少。提示Ｎｏｒｐｌａｎｔ可抑制子宫内膜ＥＲ和ＰＲ的生成，从而抑制了雌激素（Ｅ）和孕激素（Ｐ）的生物活性，其中血管壁生长不良是不规则子宫出血的主要原因之一
In order to investigate the correlation between irregular endometrium and sex hormone receptor after Norplant implantation, the normal menstrual cycle and Norplant implanted 6 months, 1 year of irregular hemorrhage in endometrial morphology and immunohistochemistry Observations of ER and PR. The results showed that there was no typical cyclical changes in the endometrium of irregular uterine bleeding; some of the endocardial vascular rupture, estrogen receptor (ER) and progesterone receptor (PR) were reduced to varying degrees. Suggesting that Norplant can inhibit the formation of endometrial ER and PR, thereby inhibiting the bioactivity of estrogen (E) and progesterone (P), in which dysplasia of the vascular wall is one of the major causes of irregular uterine bleeding