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采用免疫组织化学ABC法检测78例胃癌组织中多药材药基因产物P-糖蛋白。探讨胃癌组织中P-糖蛋白表达水平及其临床意义。结果表明，P-糖蛋白在胃癌组织中表达阳性率为42．3％（33／78）。P-糖蛋白表达在胄癌各临床分期、大体形态及组织学类型之间无显著性差异。胃癌组织中P-糖蛋白表达提示胃癌与多药耐药表型有关化疗药物的先天性耐药有关，可能是胃癌临床化疗疗效较低的重要原因。
Immunohistochemical ABC method was used to detect the multi-drug product P-glycoprotein in 78 cases of gastric cancer. To investigate the expression of P-glycoprotein in gastric carcinoma and its clinical significance. The results showed that P-glycoprotein expression in gastric cancer was 42.3% (33/78). There was no significant difference in P-glycoprotein expression between various clinical stages, general morphology and histological types of cancer. The expression of P-glycoprotein in gastric cancer suggests that gastric cancer is associated with the multidrug resistance phenotype of congenital resistance to chemotherapeutic drugs and may be an important reason for the low efficacy of clinical chemotherapy in gastric cancer.