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目的:了解2010年南京市第一医院抗菌药不良反应(ADR)发生情况及特点,为临床安全用药提供参考。方法:对2010年我院临床科室上报的266例抗菌药ADR报告,按患者性别、给药途径、药品品种及发生频率、ADR累及器官或系统及临床表现、ADR分类及严重程度分级等方面进行回顾性分析。结果:266例抗菌药ADR中,男性ADR构成比高于女性;给药途径以静脉滴注(89.85%)和口服给药(9.40%)为主;头孢菌素类、喹诺酮类及青霉素类药所致ADR占抗菌药物前3位;ADR临床表现以皮肤及附件损害以及全身性损害为主;严重ADR占全部病例的1.88%。结论:应重视与加强ADR监测与报告工作,保障患者的用药安全。
Objective: To understand the incidence and characteristics of antimicrobial adverse reactions (ADRs) in the First Hospital of Nanjing in 2010, and provide a reference for clinical safety medication. Methods: A total of 266 cases of ADR reported by clinical departments of our hospital in 2010 were analyzed according to patient’s sex, route of administration, drug variety and frequency, ADR involved organ or system and clinical manifestation, classification of ADR and grading of severity Retrospective analysis. Results: The ADR of 266 antimicrobial agents was higher than that of the female in ADR. The route of administration was intravenous drip (89.85%) and oral administration (9.40%). The cephalosporins, quinolones and penicillins ADR accounted for the first three antimicrobial drugs; ADR clinical manifestations of skin and accessory damage and systemic damage; severe ADR accounted for 1.88% of all cases. Conclusion: We should pay attention to and strengthen the work of ADR monitoring and reporting to ensure the safety of patients.