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以咖啡因为代谢探针，对203例中国健康志愿者和67例膀胱癌患者的N－乙酰化代谢表型进行了对比研究。根据人尿液中咖啡因代谢物5－乙酰氨基－6－甲酰氨基－3－甲基尿嘧啶（AFMU）和甲磷嘌呤（1X）的峰高比值绘制概率分布直方图和概率单位图，寻找区分快慢乙酰化代谢表型的临界点，确定人的乙酰化代谢表型。健康志愿者和膀胱癌患者概率分布直方图和概率单位图呈明显多态性，临界点为1．10，即大于1．10为快乙酰化代谢表型，小于1．10为慢乙酰化代谢表型。健康志愿者快、慢乙酰化代谢表型分别为149例（73．7％）和54例（26．3％）。膀胱癌患者快、慢乙酰化代谢表型分别为36例（53．7％）和31例（46．3％），二者存在显著统计学差异（P＜0．01）。志愿者和膀胱癌患者基因频率分别为0．51和0．68，优势比为2．376（95％可信区间为1．3513和个177）。中国人乙酰化代谢表型分布呈多态性。慢乙酰化代谢表型个体可能为膀胱瘤多发和易感人群。
Using caffeine as a metabolic probe, the N-acetylated metabolic phenotypes of 203 Chinese healthy volunteers and 67 patients with bladder cancer were compared. The probability distribution histograms and probability units were plotted based on the peak-to-peak ratio of caffeine metabolites, 5-acetamido-6-formamido-3-methyluracil (AFMU) and metopurine (1X) Look for the critical point to distinguish between rapid and slow acetylated metabolic phenotypes and determine the human acetylated metabolic phenotype. The probability distribution histogram and probability unit map of healthy volunteers and bladder cancer patients were significantly polymorphic with a critical point of 1.10, ie, greater than 1.10 for the fast acetylated metabolic phenotype and less than 1.10 for slow acetylated metabolism Phenotype. The fast and slow acetylated metabolic phenotypes of healthy volunteers were 149 (73.7%) and 54 (26.3%), respectively. There were 36 cases (53.7%) and 31 cases (46.3%) of fast and slow acetylated metabolic phenotype in patients with bladder cancer, respectively, with significant statistical difference (P <0.01). The frequency of genes in volunteers and bladder cancer was 0.51 and 0.68, respectively, with a odds ratio of 2.376 (95% confidence interval 1.3513 and 177). Chinese acetylated metabolic phenotypes were polymorphic. Slowly acetylated phenotypic individuals may be multiple and susceptible to bladder cancer.