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通常认为,乙酰胆碱酯酶(AChE)通过水解乙酰胆碱(ACh)影响突触传递。抑制AChE.ACh水解减少,其突触后效应增强。然而,Fossier等最近在加利福尼亚海螺(aplysia Californica)的离休口腔神经节(buccal、ganglion)制备发现,抑制AChE对乙酰胆碱受体(AChR)也有影响。Fossier等在生理营养液连续灌流下,固定该制备突触前、后神经元的膜电位,并维持突触后神经元的Cl~-翻转电位不变,观察灌流液中添加各种AChE抑制剂后该神经节中的胆碱能中间神经元对胆碱类激动剂的突触后电流(PSC)反应的变化。发现:经有机磷类AChE抑制剂处理后,该制备不仅对ACh的PSC反应增强为静息电流的269±32%,而且对不被AChE水解的卡巴可(carbachol)的反应也增强为176±7%。经氨基甲酸酯类AChE抑制剂普鲁斯的明(prostigmine)和肟类化合物contrathion(AChE有机磷中毒的复活剂,也是一种迅速可逆的AChE强抑制剂)处理后,其PSC反应类似。
It is generally accepted that acetylcholinesterase (AChE) affects synaptic transmission by hydrolyzing acetylcholine (ACh). Inhibition of AChE.ACh hydrolysis decreased, the post-synaptic effect increased. However, Fossier et al. Recently found in the reticulated buccal ganglion of aplysia californica that inhibition of AChE also affects acetylcholine receptor (AChR). Fossier and other physiological nutrition solution in a continuous perfusion fixed the preparation of pre-synaptic and post-neuronal membrane potential and maintain the post-synaptic neuronal Cl ~ - flip potential unchanged observed in the perfusion fluid added a variety of AChE inhibitors Postsynaptic currents (PSC) responses of cholinergic interneurons in the ganglia to cholinergic agonists. It was found that, after treatment with an organophosphorous AChE inhibitor, the preparation not only enhanced PSC response to ACh to 269 ± 32% of resting current but also enhanced response to carbachol not hydrolyzed by AChE to 176 ± 7%. The PSC response was similar after treatment with prostigmine and the oxime compound contrathion, a carbamate-based AChE inhibitor, a potent and rapidly reversible AChE inhibitor.