自从1924年Clarke首先从人体龋损中分离出变形链球菌,并认识到这种产酸细菌具有在人体致龋能力以来,许多学者在这方面作了大量的研究工作。1959年O(?)land 首先用实验证明对无菌大白鼠喂高蔗糖,并接种变形链球菌能引起龋损,只喂高蔗糖饲料的对照组却无龋。Zinner(1965年)证明致龋的变形链球菌无宿主专一性,实验证 Since Clarke first isolated Streptococcus mutans from human carious lesions in 1924, and realized that this acid-producing bacterium has the ability to induce caries in the human body, many scholars have done a lot of research in this field. In 1959, O (?) Land first experimentally demonstrated that feeding aseptic rats with high sucrose and inoculated with S. mutans resulted in carious lesions, whereas control animals fed only high sucrose diets were carious. Zinner (1965) demonstrated that cariogenic Streptococcus mutans were non-host specific and demonstrated experimental evidence