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目的 探讨核基质蛋白 2 2 (NMP 2 2 )在上尿路移行细胞癌诊断中的作用。 方法 对2 4例肾盂癌及输尿管癌患者和 2 0例良性泌尿系疾病患者尿中NMP 2 2浓度及尿细胞学进行检测 ,计算诊断敏感性和特异性。 结果 2 4例TCC患者尿液标本尿细胞学阳性 14例 ,NMP 2 2阳性 2 1例 ;2 0例良性泌尿系疾病患者尿液标本细胞学阳性 1例 ,NMP 2 2阳性 4例 ,NMP 2 2的诊断敏感性和特异性分别为 87.5 %和 80 .0 % ,尿细胞学为 5 8.3%和 95 .0 % ,比较二者敏感性差别有显著性意义。 结论 NMP 2 2可能成为检测上尿路移行细胞癌的良好辅助手段
Objective To investigate the role of nuclear matrix protein 2 2 (NMP 2 2) in the diagnosis of transitional cell carcinoma of the upper urinary tract. Methods The urinary NMP 2 2 concentrations and urinary cytology in 24 patients with renal pelvic and ureteral carcinoma and 20 patients with benign urological diseases were measured, and the diagnostic sensitivity and specificity were calculated. Results Twenty-four urinary samples from 24 patients with TCC were positive for urinary cytology and 21 were positive for NMP 2 2. Urine samples were positive for cytology in 20 patients with benign urological diseases, 4 were positive for NMP 2 2, 2 were positive for NMP 2 2 The diagnostic sensitivity and specificity of 2 were 87.5% and 80.0%, respectively. The urinary cytology was 53.3% and 95.0% respectively. There was significant difference between the two in sensitivity. Conclusion NMP 2 2 may be a good adjunct to detecting upper urinary tract transitional cell carcinoma