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目的:研究注射用清开灵冻干粉(QKLFDPI)的体内抗流感病毒作用。方法:流感病毒滴鼻感染小鼠,肌注给药,观察记录动物发病数及死亡数、生存时间等,并观察死亡动物肺病变充血程度,同时取肺标本进行病毒培养和血凝效价测定。结果:与病毒对照组比:QKLFDPI组感染小鼠存活时间明显延长,小鼠的存活率明显提高,肺充血程度减轻,病毒复制受到抑制。其抑制流感病毒复制的半数有效剂量为187mg/kg,治疗指数(TI)为5.35。结论:QKLFDPI对流感病毒感染小鼠具有明显保护作用。
Objective: To study the in vivo anti-influenza virus effect of Qingkailing lyophilized powder (QKLFDPI) for injection. Methods: Influenza virus was injected intranasally into mice and administered intramuscularly. The number of animals and the number of deaths and the survival time were observed. The degree of congestion in the lungs of the dead animals was observed. At the same time, lung samples were taken for virus culture and hemagglutination. . RESULTS: Compared with the virus control group, the survival time of infected mice in the QKLFDPI group was significantly longer, the survival rate of the mice was significantly increased, the degree of pulmonary congestion was reduced, and virus replication was inhibited. Its half effective dose for inhibiting influenza virus replication was 187 mg/kg, and the therapeutic index (TI) was 5.35. Conclusion: QKLFDPI has obvious protective effect on influenza virus infected mice.