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目的：研究脂必妥的降脂疗效。方法：通过对大鼠腹腔注射脂酶抑制剂——１０％泰洛沙泊溶液（３ｍＬ／ｋｇ）后７ｍｉｎ，分别用脂必妥２．５９，１．２９，０．６５ｇ／ｋｇ，及洛伐他汀１０ｍｇ／ｋｇ灌胃给药。结果：脂必妥２．５９ｇ／ｋｇ组及洛伐他汀组（１０ｍｇ／ｋｇ）的胆固醇（ＴＣ）值分别降低３３％（Ｐ＜０．０１）及３１％（Ｐ＜０．０１），组间比较Ｐ＞０．０５；低密度脂蛋白胆固醇（ＬＤＬ－ｃｈ）值分别降低５０％（Ｐ＜０．０１）及４４％（Ｐ＜０．０１）；脂必妥１．２９ｇ／ｋｇ组亦能降低ＴＣ及ＬＤＬ－ｃｈ值１８％（Ｐ＜０．０５）及２６％（Ｐ＜０．０５）；小剂量０．６５ｇ／ｋｇ的脂必妥仅能降低ＴＣ１４％（Ｐ＜０．０５）；各组对三酰甘油（ＴＧ）值均无显著降低作用（Ｐ＞０．０５）。结论：脂必妥有显著降低血脂过多大鼠ＴＣ及ＬＤＬ－ｃｈ值的作用。
Objective: To study the lipid-lowering effect of Lipitor. Methods: The rats were injected intraperitoneally with lipase inhibitor - 10% tyloxapol (3mL / kg) for 7min, respectively, with Lipidophil 2.59,1.29,0.65g / kg, and Los Statin 10mg / kg intragastric administration. Results: The cholesterol (TC) of 2.59g / kg and lovastatin groups decreased by 33% (P <0.01) and 31% (P <0.01) (P <0.01) and 44% (P <0.01) respectively. The level of LDL-ch was 1.29g / kg TC and LDL-ch also decreased by 18% (P <0.05) and 26% (P <0.05), respectively. (P <0.05). There was no significant decrease in triglyceride (TG) in each group (P> 0.05). Conclusion: Lipid may significantly reduce the hyperlipidemia rats TC and LDL-ch value.