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检测３０例高胆固醇血症病人和３０例正常人血清一氧化氮（Ｓ－ＮＯ）、血清过氧化脂质（Ｓ－ＬＰＯ）的含量，并进行了统计学处理。结果表明，高胆固醇血症病人与正常人比较，Ｓ－ＮＯ水平显著下降（Ｐ＜０．００１）；而Ｓ－ＬＰＯ含量明显增高（Ｐ＜０．００１）。从自由基生物学的角度探讨了高胆固醇血症一氧化氮、脂质过氧化自由基之间的关系，以及在动脉粥样硬化中的临床意义
The levels of serum nitric oxide (S-NO) and serum lipoperoxidase (S-LPO) in 30 patients with hypercholesterolemia and 30 normal persons were detected and statistically analyzed. The results showed that patients with hypercholesterolemia had significantly lower levels of S-NO (P <0.001) and higher levels of S-LPO (P <0.001) than those of normal subjects. The relationship between nitric oxide and lipid peroxidation in hypercholesterolemia and its clinical significance in atherosclerosis were discussed from the viewpoint of free radical biology