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DNA甲基化作为表观遗传现象的分子基础由Holliday和Pugh于20世纪70年代发现[1]。表观遗传是指DNA序列不发生变化但基因表达却发生了可遗传改变,这些信息能经有丝分裂和减数分裂在细胞和个体世代间传递,而不借助于DNA序列的改变,即表观遗传是非DNA序列差异的核遗传[2-3]。DNA甲基化是表观遗传学重要改变之一。研究表明,除遗传机制外,环境因素还可通过表观遗传机
The molecular basis of DNA methylation as an epigenetic phenomenon was discovered by Holliday and Pugh in the 1970s [1]. Epigenetic refers to the DNA sequence does not change but the gene expression has undergone a genetic change, the information can be mitosis and meiosis in the cell and individual transmission between cells and individuals, without resorting to changes in DNA sequences that epigenetic Non-DNA sequence differences in nuclear inheritance [2-3]. DNA methylation is one of the major changes in epigenetics. Research shows that in addition to genetic mechanisms, environmental factors can also pass epigenetic machines