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应用抗细胞角蛋白单克隆抗体ＡＥ１／ＡＥ３，对部分非上皮组织和细胞，以及上皮来源的恶性肿瘤如乳腺癌、肿癌和鼻咽癌组织和细胞的角蛋白表达进行了研究。结果表明，ＡＥ１／ＡＥ３对骨髓、外周血、淋巴结和淋巴瘤的组织和细胞基本无交叉反应，而对上述癌组织和细胞则有不同程度的反应。所以，在病理诊断中ＡＥ１／ＡＥ３常被用于鉴别疑难肿瘤的组织来源。但因个别间叶组织对ＡＥ１／ＡＥ３亦呈阳性反应，而个别上皮肿瘤却为阴性反应，所以必须多因素综合分析。ＡＥ１／ＡＥ３对乳腺癌、非小细胞肺癌的组织和单个细胞有很强且均匀的反应，可用来做微小转移的探针。该项研究的例数较少，仅为ＡＥ１／ＡＥ３的临床应用提供参考
Using anti-cytokeratin monoclonal antibody AE1/AE3, the keratin expression of some non-epithelial tissues and cells, as well as epithelial-derived malignant tumors such as breast cancer, tumorous tumors, and nasopharyngeal cancer tissues and cells was studied. The results showed that AE1/AE3 had almost no cross-reactions with bone marrow, peripheral blood, lymph node, and lymphoma tissues and cells, but had different degrees of response to the aforementioned cancer tissues and cells. Therefore, AE1/AE3 is often used as a tissue source for identifying difficult tumors in pathological diagnosis. However, due to individual mesenchymal tissue positive reaction to AE1/AE3, and individual epithelial tumors are negative, it must be comprehensive analysis of multiple factors. AE1/AE3 has a strong and uniform response to breast cancer, non-small cell lung cancer tissues and single cells, and can be used as a probe for micrometastases. The number of cases in this study is small and only provides reference for the clinical application of AE1/AE3