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目的探讨研究P27在食管鳞癌患者中的检验价值。方法以2010年9月～2012年12月收集的食管鳞癌患者45例为临床研究对象，选取食管鳞癌标本、癌旁正常食管上皮组织，使用免疫组织化学P V-9000非生物素二步检查方法对标本进行P27检查，观察检测结果。结果食管鳞癌的P27阳性率明显低于正常上皮组织，组间比较，p＜0.05，差异有统计学意义。结论 P27在食管癌的表达有明显降低，其可能参与到食管鳞癌的发生和发展中，检测P27有助于对食管鳞癌进行早期的诊断。“,” Objective: To investigate the test value of p27 in patients with esophageal squamous cel carcinoma. Methods: September 2010 to December 2012, 45 patients with esophageal squamous cel carcinoma clinical research object, select the esophageal squamous cel carcinoma and adjacent normal esophageal epithelium, immunohistochemical PV-9000 non-biotin two-step The inspection method of specimens P27 examination, observation of the detection result. Results: esophageal squamous cel carcinoma P27 positive rate was significantly lower than that in normal epithelial tissue between the two groups, P ﹤0.05, the difference was statistical y significant. Conclusion: p27 expression in esophageal cancer have significantly reduced, which may be involved in the occurrence and development of esophageal squamous cel carcinoma, the detection P27 help early diagnosis of esophageal squamous cel carcinoma.