慢性粒细胞性白血病(CML)是一种纯系骨髓增生性疾患,起源于多能干细胞的恶性转变。临床特征为粒细胞明显增多,也涉及到其它血细胞系,如红细胞系、巨核细胞系。经Dameshek等统计,西方国家CML占白血病的20～30%,每年发病率为1/100000。引起CML发生的特殊病因尚不明了,但很多事实表明,CML是一种获得性疾病。动物实验表明,CML可为多种 Chronic myelogenous leukemia (CML) is a pure myeloproliferative disorder that originates from the malignant transformation of pluripotent stem cells. Clinical features are markedly increased granulocytes, but also involves other blood cell lines, such as red blood cell lines, megakaryocyte cell lines. According to Dameshek et al., CML in Western countries accounts for 20-30% of leukemia, and the annual incidence rate is 1/100000. The specific cause of CML is unclear, but many facts indicate that CML is an acquired disease. Animal experiments show that CML can be multiple