我们将体重2.5～3kg的家兔分为3组,每组7只。每日插胃管灌入噻氯匹啶50mg/kg,100mg/kg或不给药,连续7d。观察出血时间与血小板聚集的变化,并研究了Cattaneo主动脉血栓模型的血栓形成情况及有关指标的改变。结果表明:①50mg/kg组出血时间从2.3±0.8min延长至4.5±1.4min(P<0.01),100mg/kg组出血时间从2.8±0.8min延 We divided the body weight of 2.5 ~ 3kg rabbits into 3 groups of 7. The daily addition of gastric tube into the ticlopidine 50mg / kg, 100mg / kg or not, for 7d. The changes of hemorrhage time and platelet aggregation were observed. The thrombosis of Cattaneo aortic thrombosis model and the changes of related indexes were also studied. The results showed that: ①50mg / kg bleeding time from 2.3 ± 0.8min to 4.5 ± 1.4min (P <0.01), 100mg / kg bleeding time from 2.8 ± 0.8min