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目的:探讨肿瘤转移与血浆DNA水平之间的关系,评价早期诊断肿瘤转移的方法。方法:将人肺腺癌SPC-A1细胞接种到BALB/c小鼠腹腔,每周定期检测血浆DNA水平,7周后处死小鼠,观察肿瘤形成及转移情况。结果:小鼠血浆DNA水平呈升高趋势的占75.6%(34/45只);其中接种后第3周起血浆DNA水平均比接种后第1周显著升高(P﹤0.05)。血浆DNA水平升高及持续升高组小鼠中有肺转移瘤形成的占73.5%(25/34只)。无升高组小鼠中有肺转移瘤形成的占27.3%(3/11只)。血浆DNA水平升高组及持续升高组均显著高于无升高组(P﹤0.05)。血浆DNA水平与肿瘤负荷正相关(R2=0.8703)。结论:形成肺转移瘤的BALB/c小鼠血浆DNA水平在早期即显著升高,血浆DNA水平可用于肿瘤转移的早期监测。
OBJECTIVE: To investigate the relationship between tumor metastasis and plasma DNA level and evaluate the method of early diagnosis of tumor metastasis. Methods: Human lung adenocarcinoma SPC-A1 cells were inoculated into the peritoneal cavity of BALB / c mice. Plasma DNA level was measured regularly every week. After 7 weeks, the mice were killed and the formation and metastasis of tumor were observed. Results: The plasma DNA level in mice showed a trend of 75.6% (34/45). The plasma DNA level in the third week after inoculation was significantly higher than that in the first week after inoculation (P <0.05). 73.5% (25/34) patients had lung metastases in the plasma DNA level rising and rising group mice. There were 27.3% (3/11) of lung metastases in non-elevated mice. Plasma DNA level increased group and continued to increase the group were significantly higher than the non-elevated group (P <0.05). Plasma DNA levels correlated positively with tumor burden (R2 = 0.8703). CONCLUSION: Plasma DNA levels in BALB / c mice that form lung metastases are significantly elevated early and plasma DNA levels can be used for early monitoring of tumor metastases.