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目的:分析连续性静脉-静脉血液滤过（continuous venovenous hemofiltration，CVVH）在治疗危重型手足口病中的临床价值。方法:回顾性收集2014—2017年住院的危重型手足口病患儿55例，分为CVVH组（23例）和对照组（32例）。对照组给予免疫球蛋白、地塞米松、甘露醇及米力农、艾司洛尔等血管活性药物、机械通气等治疗，CVVH组在上述治疗的基础上加用连续性静脉-静脉血液滤过，分析两组患儿在治疗第3天和第5天时的体温、心率、血压及外周血白细胞、血糖、乳酸等方面的差异，分析两组患儿病情进展情况、病死率及并发症发生率。结果:对照组20例3期患儿中，15例进展为4期；CVVH组15例3期患儿中，2例进展为4期，两组比较差异有统计学意义（n x2=13.049，n P0.05）。n 结论:血液净化可阻断3期危重型手足口病患儿的病情进展至4期，缩短气管插管呼吸机辅助通气时间。“,”Objective:To analyze the clinical value of continuous venovenous hemofiltration (CVVH) in the treatment of severe hand, foot, and mouth disease (HFMD).Methods:A total of 55 hospitalized patients of severe HFMD in the hospital from 2014 to 2017 was retrospectively collected. The cases were divided into CVVH group (n n=23) and control group (n n=32). The control group received treatments of immunoglobulin, dexamethasone, mannitol and vasoactive agents, including milrinone and esmolol as well as ventilator ventilation. The CVVH group was treated with continuous hemofiltration on the basis of above-mentioned treatments. The differences of body temperature, heart rate, blood pressure and peripheral blood leucocyte, blood glucose and lactate between the two groups at the third day and the fifth day of treatment were compared, and the progression, mortality and incidence of complications in the two groups were also analyzed.n Results:Fifteen cases in control group and 2 cases in CVVH developed into stage 4. The difference was statistically significant (n x2=13.049, n P0.05).n Conclusions:Continuous hemofiltration can effectively block the progress of the disease from stage 3 to stage 4 and will shorten time of ventilator ventilation.