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目的:探讨苯二氮卓类药物对急性心肌梗死伴焦虑患者治疗后心律失常、梗死后心衰发生率和焦虑改善情况的影响。方法:将273例经汉密尔顿焦虑量表评价为焦虑的且未行经皮冠状动脉介入术的心肌梗死患者随机分为实验组140例和对照组133例,实验组在对照组治疗的基础上给予口服地西泮2.5mg,每天3次和艾司唑仑片1mg睡前口服,比较2组患者治疗后心律失常发生率、梗死后心衰发生率、焦虑改善情况及死亡率的水平。结果:2组在心律失常发生率、梗死后心衰发生率及焦虑改善情况的差异均有统计学意义(P均<0.05)死亡率的差异无统计学意义(P>0.05)。结论:苯二氮卓类药物能减少急性心肌梗死伴焦虑患者治疗后心律失常、梗死后心衰的发生,改善焦虑状况,值得临床推广。
Objective: To investigate the effect of benzodiazepines on the improvement of cardiac arrhythmia, the incidence of post-infarction heart failure and anxiety in patients with acute myocardial infarction and anxiety. Methods: A total of 273 myocardial infarction patients who were evaluated as anxiety by the Hamilton Anxiety Scale and who underwent no percutaneous coronary intervention were randomly divided into experimental group (140 cases) and control group (133 cases). The experimental group was given oral treatment on the basis of the control group Diazepam 2.5mg, 3 times a day and 1mg of estazolam before bedtime oral administration, compared the incidence of arrhythmia after treatment in two groups, the incidence of post-infarction heart failure, anxiety improvement and mortality levels. Results: There was no significant difference in the incidence of arrhythmia, the incidence of post-infarction heart failure and the improvement of anxiety between the two groups (all P <0.05) (P> 0.05). Conclusion: Benzodiazepines can reduce arrhythmia and heart failure after acute myocardial infarction with anxiety in patients with post-infarction, and improve anxiety. It is worthy of clinical promotion.