目的研究乙型肝炎（乙肝）肝内血管增生与肝病变的关系．方法肝活检标本１６０７例取自住院乙肝患者，另选大致正常肝组织１０例作对照．石蜡包埋，４μｍ连续切片，作网状、胶原、弹力纤维组织化学及αＳＭＡ，ＦＮ，ＬＮ，ＣⅣ免疫组织化学标记．结果在正常肝组织αＳＭＡ仅在原有的肝内动静脉及胆管壁表达．ＦＮ肝细胞示阳性．在乙肝病变较轻组血管间隔及坏死区αＳＭＡ，ＦＮ，ＬＮ，ＣⅣ示强阳性；在乙肝病变较重组桥形纤维化及肝窦毛细血管化区上述物质多示强阳性；在肝硬变组假小叶的纤维带、血管生成区、坏死灶、纤维带与肝实质交接部位、毛细血管化区域、窦内皮细胞其示强阳性表达．结论肝内血管增生对引起肝纤维化及肝硬变有重要的作用 Objective To study the relationship between hepatitis B (hepatitis B) intrahepatic vascular hyperplasia and liver disease. Methods A total of 1607 liver biopsy specimens were collected from hospitalized patients with hepatitis B, and another 10 cases of normal liver tissue were selected as control. Paraffin-embedded, 4μm serial sections for reticular, collagen, elastic fiber histochemistry and α  SMA, FN, LN, C  IV immunohistochemical markers. Results in normal liver α  SMA only in the original hepatic artery and vein and bile duct wall expression. FN liver cells showed positive. Serum positive αSMA, FN, LN and C  Ⅳ showed strong positive in vessel spacing and necrosis area of ​​mild hepatitis B group. In the more severe group of hepatitis B lesion more bridged fibrosis and cirrhosis capillary area, Cirrhotic group false lobule fibrosis, angiogenesis, necrosis, fiber junction with the liver parenchyma, capillary area, sinus endothelial cells strongly positive expression. Conclusion Intrahepatic vascular hyperplasia has an important role in causing hepatic fibrosis and cirrhosis