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目前,研究肿瘤的热点已经从癌基因转到抑癌基因,在已发现的抑癌基因中,Survivin,nm23,NS.398与宫颈癌的关系密切,也是宫颈癌研究的热点。宫颈癌(CervicalCarcinoma)是最常见的妇科恶性肿瘤之一,仅次于乳腺癌,占女性生殖系统恶性肿瘤的半数以上,其死亡率居女性恶性肿瘤的首位,是严重危害妇女健康和生命的主要疾病之一。宫颈癌的发病机制复杂,目前尚不完全清楚,现有的研究表明宫颈癌的发生、发展是由宫颈不典型增生(轻到中到重)、原位癌、早期浸润癌、浸润癌的连续发展过程,是一个多基因参与的多步骤的复杂过程,其中抑癌基因功能的丧失和癌基因的表达是其细胞癌变的分子基
At present, the study of tumor hot spots has been transferred from oncogene to tumor suppressor gene. Among the found tumor suppressor genes, Survivin, nm23 and NS.398 are closely related to cervical cancer, which is also a hot research topic of cervical cancer. CervicalCarcinoma is one of the most common gynecological malignancies, second only to breast cancer, which accounts for more than half of the female reproductive system malignancies. Its mortality rate ranks first among women’s malignancies and is the major hazard to women’s health and life One of the diseases. The pathogenesis of cervical cancer is complex and not yet fully understood. The existing studies have shown that the occurrence and development of cervical cancer are caused by the progression of atypical hyperplasia (mild to moderate to severe), carcinoma in situ, early invasive carcinoma and invasive carcinoma Development process is a multi-step multi-gene involved in the complex process, in which loss of function of tumor suppressor genes and oncogenes is the molecular basis of their cancerous cells