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目的：探讨氧化型低密度脂蛋白（Ｏｘ—ＬＤＬ）对老年脑梗死的作用及影响。方法：对３０例老年脑梗死患者进行了血浆Ｏｘ－ＬＤＬ、高密度脂蛋白－Ｃ，（ＨＤＬ—Ｃ）、低密度脂蛋白－Ｃ，（ＬＤＬ—Ｃ）、Ｃｈｏ、ＴＧ、ａｐｏＡ、ａｐｏＢ，血浆内皮素水平测定，同时观察血液流变学指标，并与 ２３例健康老年人对照。结果：老年脑梗死组血浆 Ｏｘ— ＬＤＬ、内皮素水平明显增高； ＬＤＬ－ Ｃ、Ｃｈｏ、ＴＧ与对照组比较亦增高；ＨＤＬ—Ｃ降低，血液流变学指标明显异常，而且Ｏｘ－ＬＤＬ的变化与血浆内皮素水平、血液流变学指标呈正相关，与ＨＤＬ－Ｃ、 ＬＤＬ－Ｃ、Ｃｈｏ、ＴＧ、ａｐｏＡ、ａｐｏＢ无明显相关性。结论：Ｏｘ－ＬＤＬ导致动脉粥样硬化，促进血浆内皮素分泌，影响血液流变性，引起脑缺血、缺氧促进脑梗死的发生和发展。
Objective: To investigate the effect of oxidized low density lipoprotein (Ox-LDL) on senile cerebral infarction. Methods: Thirty patients with senile cerebral infarction were enrolled in this study. The plasma levels of Ox-LDL, HDL-C, LDL-C, Cho, TG, apoA, apoB, Plasma endothelin levels were measured, meanwhile hemorheological indexes were observed and compared with 23 healthy controls. Results: Compared with the control group, LDL-C, Cho and TG were also increased in the aged group with cerebral infarction; the level of HDL-C was decreased and the index of hemorheology was abnormal. And the change of Ox-LDL And plasma endothelin levels, hemorheological indicators was positively correlated with HDL-C, LDL-C, Cho, TG, apoA, apoB no significant correlation. Conclusion: Ox-LDL can induce atherosclerosis, promote plasma endothelin secretion, affect hemorrheology, cause cerebral ischemia and hypoxia, and promote the occurrence and development of cerebral infarction.