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尽管乙型肝炎病毒(HBV)疫苗对预防HBV的慢性携带高度有效,但在接种疫苗的儿童中已有发生以抗-HBc阳性为特征的失保护性感染(break through infection)的报道。在接受HBV疫苗和HB-特异抗体的儿童中也有关于逃逸变异株的描述。本文报告了单独接受疫苗后发生失保护性感染儿童中的抗-HBs消失与接种疫苗产生抗-HBs抗体应答峰值之间的关系,以及从上述儿童中检出的1株HBV变异株的鉴定。 385名冈比亚乡村新生儿自1984年起接受血源疫苗,均于1、2、4和9月龄时接种,并于11月龄时采血测定抗-HBs应答的峰
Although hepatitis B virus (HBV) vaccines are highly effective in preventing the chronic carriage of HBV, reports of break through infections characterized by anti-HBc have been reported in vaccinated children. There are also descriptions of escape variants in children receiving HBV vaccines and HB-specific antibodies. This paper reports the relationship between the disappearance of anti-HBs in children with protective-protective infection after vaccination alone and the peak of the anti-HBs antibody response to vaccination, as well as the identification of a single HBV variant detected in these children. 385 Gambian country-born newborns received blood-borne vaccines since 1984 and were vaccinated at 1, 2, 4 and 9 months of age and collected blood at 11 months of age to measure the peak of the anti-HBs response