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目的 探讨中西医结合治疗成人激素依赖性 (SD)原发性肾病综合征 (PNS)的临床疗效。方法 6 2例成人SD PNS分为治疗组和对照组。治疗组 31例用强的松和环磷酰胺 (CTX)并根据激素不同阶段加用中药 ,对照组 31例单纯用西药治疗。观察临床完全缓解率、复发率、缓解时间和不良反应。结果 治疗组完全缓解率为 74.2 % ,对照组为 38.7% ,有显著性差异 (P <0 .0 1) ;治疗组 1、2、4年的复发率为 0、4.4%、13% ,对照组为 8.3%、16 .6 %、41.6 % ,2组比较差异显著 (P <0 .0 5 ) ;治疗组平均缓解期为 (33.6± 3.9)月 ,对照组为 (13.4± 3.2 )月 ,治疗组显著长于对照组 (P <0 .0 1) ;治疗组不良反应为 32 .2 % ,对照组为87.1% ,治疗组显著低于对照组 (P <0 .0 1)。结论 中西医结合治疗方法能提高成人SD PNS的完全缓解率 ,减少复发和不良反应。
Objective To investigate the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of adult hormone-dependent primary nephrotic syndrome (PNS). Methods 6 2 adult SD PNS were divided into treatment group and control group. 31 cases of treatment group with prednisone and cyclophosphamide (CTX) and according to different stages of hormone plus traditional Chinese medicine, control group of 31 patients treated with Western medicine alone. Clinical complete response rate, recurrence rate, remission time and adverse reactions were observed. Results The complete remission rate was 74.2% in the treatment group and 38.7% in the control group, with significant difference (P <0.01). The recurrence rates at 1, 2 and 4 years in the treatment group were 0, 4.4% and 13% (P <0.05). The average remission time was 33.6 ± 3.9 months in the treatment group and (13.4 ± 3.2) months in the control group, with a significant difference between the two groups (8.3%, 16.6%, 41.6% The treatment group was significantly longer than the control group (P <0.01). The adverse reaction rate was 32.2% in the treatment group and 87.1% in the control group, which was significantly lower in the treatment group than in the control group (P <0.01). Conclusion Integrative treatment can improve the complete remission rate of adult SD PNS and reduce the recurrence and adverse reactions.