论文部分内容阅读
目的:分析中药复方“松友饮”体内、外抑癌作用。方法:明确“松友饮”的组方成份,总结前期相关研究结果,提出尚需进一步研究内容。结果:“松友饮”为5味中药提取物,已分析获得高效液相指纹图谱,为“松友饮”提供质控参考。“松友饮”通过抑制MMP2抑制肝癌(HCC)侵袭性;连续7天灌胃给药增强小鼠免疫功能。连续5周灌胃抑制术后残癌组织IL–1β和PCNA表达,抑制裸鼠模型HCC生长、转移,延缓裸鼠体重下降,延长生存期,增强干扰素(抑制HCC。给药7天的含药血清达到稳态血药浓度,对HCC体外抑制作用最强。该复方已开展临床研究,但药效物质基础仍需深入研究。结论:“松友饮”具有体内、外抑制HCC生长、转移作用,具有潜在临床应用价值。
Objective: To analyze the effect of traditional Chinese medicine compound “Songyouyin” on tumor suppression in vivo and in vitro. Methods: It is clear that the ingredients of “Song Youyin” can be summarized and the results of previous studies are summarized, and further research is needed. Results: “Songyouyin ” is a Chinese herbal extract with 5 flavors. HPLC fingerprinting has been obtained to provide quality control reference for “Songyouyin”. “Songyouyin ” inhibits the invasiveness of liver cancer (HCC) by inhibiting MMP2; gavage administration for 7 days continuously enhances the immune function of mice. The expression of IL-1β and PCNA in gastric cancer tissues after 5-week gastric perfusion was inhibited, the growth and metastasis of HCC in nude mice were inhibited, the weight loss of nude mice was delayed, the survival was prolonged, and the interferon (HCC suppression was inhibited) The drug serum reached steady state blood concentration and had the strongest inhibitory effect on HCC in vitro.The clinical research of this compound has been carried out, but the basis of pharmacodynamic substance still needs further study.Conclusion: “Song Youyin” can inhibit the growth of HCC in vitro and in vivo, Metastasis, with potential clinical value.