肿瘤多药耐药(MDR)是近年来肿瘤治疗研究的困扰之一,其产生机制非常错综复杂。随着对非P-糖蛋白介导MDR机制研究的不断深入,肺耐药相关蛋白(LRP)被证实在MDR中发挥着重要作用,有望成为一种新的治疗靶点。本文就LRP的生理特性、分布、耐药机制、检测手段、临床意义及其介导的MDR逆转做一简要综述。 Tumor multidrug resistance (MDR) is one of the problems in cancer therapy in recent years, and its mechanism is very complicated. With the deepening of the research on the mechanism of non-P-glycoprotein mediated MDR, LRP has been proved to play an important role in MDR and is expected to become a new therapeutic target. This article gives a brief overview of the physiological characteristics, distribution, drug resistance mechanism, detection means, clinical significance and the MDR reversal of LRP.