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目的：探讨淋巴瘤患者糠皮质激素（GC）疗效与糖皮质激素受体（GCR）之间的关系。方法：测定40例淋巴瘤患者的外周血白细胞GCR水平。结果：治疗有效组患者的GCR水平显著高于治疗无效组，高GCR水平组患者（GCR＞1920位点／细胞）的治疗有效率显著高于低GCR水平组（GCR＜1920位点／细胞），GCR水平与GC疗效之间呈显著相关。结论：对GCR水平极低的患者，联合应用抗肿瘤药物可能较盲目加大激素剂量更为适宜。
Objective: To investigate the relationship between the effect of corticosteroid (GC) and glucocorticoid receptor (GCR) in patients with lymphoma. Methods: The peripheral blood leukocyte GCR levels were measured in 40 patients with lymphoma. RESULTS: The GCR level was significantly higher in the active-treatment group than in the treatment-negative group, and the treatment efficiency was significantly higher in the high-GCR group (GCR>1920/cell) than in the low-GCR group (GCR <1920/cell). There was a significant correlation between GCR levels and GC efficacy. Conclusion: In patients with very low GCR levels, combined use of anti-cancer drugs may be more appropriate than blindly increasing hormone doses.