论文部分内容阅读
采用雄性3月龄Wistar大鼠(体重180～220g)350只,分7组:(1)香花岭Ⅰ号矿尘组(含砷32.0％),6mg/次;(2)香花岭Ⅱ号矿尘(含砷2.2％),6mg/次;(3)香花岭Ⅲ号矿尘(含砷0.54％),6mg/次;(4)广西大厂锡矿选厂粉尘(含砷1.9％),6mg/次;(5)生理盐水对照组,0.2ml/次;(6)自然对照组;(7)3-MCA阳性对照组,10mg,只注一次。每组50只大鼠。粉尘粒子直径在10μm以下者占90％。大鼠乙醚麻醉,气管内灌0.2ml生理盐水粉尘混悬液,每周一次,共10次。实验期限为二年。病理常规方法。每组诱发肺癌结果分别为:(1)2/38(5.0％),(2)2/48(4.0％);(3)2/46(4.0％);(4)0/42;(5)0/44;(6)4/31(12.9％)。结果表明各组肺癌诱发率与矿尘中的含砷量并无剂量-反应关系。
A total of 350 male Wistar rats of 3 months old weighing 180-220 g were divided into 7 groups: (1) Xiangfengling mine dust group (32.0%) with 6mg / time; (2) (3) Xiangfengling Ⅲ ore dust (containing arsenic 0.54%), 6mg / time; (4) Guangxi Dachang tin mining plant dust (containing arsenic 1.9%), 6mg / time; (5) saline control group, 0.2ml / time; (6) natural control group; (7) 3-MCA positive control group, 10mg, injection only once. 50 rats per group. Dust particle diameter of 10μm or less accounted for 90%. Rat ether anesthesia, tracheal instillation 0.2ml saline suspension, once a week, a total of 10 times. The experimental period is two years. Pathological methods. Results of each group were as follows: (1) 2/38 (5.0%), (2) 2/48 (4.0%); (3) 2/46 (4.0%); (4) 0/42; ) 0/44; (6) 4/31 (12.9%). The results showed that there was no dose-response relationship between the induction rate of lung cancer and the arsenic content in the dust in each group.