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DG-5128的化构与一般降糖药不同。由于它对链尿霉素诱发大鼠糖尿病几乎不起作用,因而推想其降糖作用与磺酰脲类一样是刺激胰岛素的释放。但它对遗传性糖尿病小鼠有效,而甲磺丁脲对该小鼠无效,这种差别使作者对二者的作用方式作一对比研究。 作者将DG-5128 14mg/kg或甲磺丁脲20mg/kg注入禁食一夜的大鼠尾静脉,血浆中胰岛素急剧升高,随之血糖明显下降。在口服糖耐量的实验中,
The structure of DG-5128 is different from that of common hypoglycemic agents. Since it has little effect on streptozotocin-induced diabetic rats, it is hypothesized that its hypoglycemic action, like sulfonylureas, stimulates the release of insulin. However, it is effective in hereditary diabetic mice, and metoxicamide is ineffective in this mouse, a difference that allows the authors to make a comparative study of the two modes of action. The author will DG-5128 14mg / kg or metsulfuride 20mg / kg injected into the tail of a rat fasted overnight, a sharp rise in plasma insulin, followed by significant decline in blood glucose. In the oral glucose tolerance test,