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目的:探讨可比特氧驱雾化吸入在重度哮喘治疗中的临床应用。方法:将156例重度哮喘患者随机分为治疗组123例和对照组33例,对照组给予综合治疗,治疗组在此基础上给予氧气驱动雾化吸入可比特治疗。根据氧气驱动流量4、6、8 L/min分为A组40例、B组41例、C组42例三组;同时分为面罩组63例和口含喷嘴组60例。观察各组患者治疗前、治疗后72 h临床疗效。结果:治疗后总有效率B组和C组明显高于A组和对照组(P<0.05),面罩组明显高于口含嘴组(P<0.05)。喘憋症状消失时间、哮鸣音消失时间、甲强龙用量、甲强龙应用天数及总住院天数B组和C组明显少于对照组和A组(P<0.05),面罩组少于口含嘴组(P<0.05)。结论:可比特氧驱雾化吸入治疗重度哮喘临床疗效显著,氧气驱动流量6 L/min疗效理想,面罩式好于口含喷嘴式。
Objective: To investigate the clinical application of inhalable oxygen inhalation in patients with severe asthma. Methods: A total of 156 patients with severe asthma were randomly divided into treatment group (123 cases) and control group (33 cases). The control group was given comprehensive treatment. On the basis of this, the treatment group was given oxygen-driven atomization inhalation and bit treatment. According to oxygen-driven flow rate of 4,6,8 L / min, there were 40 patients in group A, 41 patients in group B, and 42 patients in group C, and 63 patients in mask group and 60 patients in nozzle group. The clinical efficacy of each group before and 72 h after treatment was observed. Results: After treatment, the total effective rate in group B and group C was significantly higher than that in group A and control group (P <0.05), and that in mask group was significantly higher than that in mouth group (P <0.05). Wheezing disappeared, the time of wheezing disappeared, the dosage of methylprednisolone, the days of application of methylprednisolone, and the total number of days of hospital stay in group B and group C were significantly less than those in control group and group A (P <0.05) Mouth group (P <0.05). CONCLUSION: Oxygen inhalation inhalation is effective in treating severe asthma. Oxygen-driven flow rate of 6 L / min is effective, and the mask is better than the nozzle with nozzle.