论文部分内容阅读
目的:评价利加隆联合恩替卡韦治疗慢性乙型肝炎临床疗效及乙型肝炎病毒脱氧核糖核酸(HBV-DNA)转阴率的近期疗效。方法:采用随机、双盲、平行对照的方法,122例伴有谷丙转氨酶(ALT)升高的慢乙肝患者分为两组:治疗组62例;给予利加隆联合恩替卡韦治疗,对照组60例,给予恩替卡韦治疗,其他治疗两组相同,均未使用免疫调节药物及糖皮质激素,检测用药前后两组患者谷丙转氨酶、总胆红素、白蛋白和血清肝纤维化指标及HBV-DNA的变化。结果:恩替卡韦联合利加隆的治疗组血清肝纤维化指标(透明质酸、层粘蛋白、IV型胶原)和肝功能指标(谷氨转氨酶、总胆红素)下降明显,白蛋白上升明显,分别与治疗前和对照组比较,差异具有统计学意义(P<0.05)。两组患者在治疗3、6个月时HBV-DNA转阴率比较,差异无统计学意义(P>0.05)。结论:利加隆联合恩替卡韦在慢性乙型肝炎患者肝功能恢复正常,血清肝纤维化指标下降等方面的作用优于单独使用恩替卡韦,但两种方法对慢性乙型肝炎病毒下降水平,差异无统计学意义(P>0.05)。
OBJECTIVE: To evaluate the short-term efficacy of the combination of lialolone and entecavir in the treatment of chronic hepatitis B and the negative conversion rate of hepatitis B virus DNA (HBV-DNA). Methods: A total of 122 patients with chronic hepatitis B accompanied with alanine aminotransferase (ALT) elevation were divided into two groups by randomized, double-blind and parallel control: 62 in the treatment group, 35 in the treatment group and 60 in the control group , Given entecavir treatment, the other treatment of the same two groups, did not use immunomodulatory drugs and glucocorticoid, test before and after treatment in patients with alanine aminotransferase, total bilirubin, albumin and serum liver fibrosis indicators and HBV-DNA Variety. Results: Serum levels of hepatic fibrosis (hyaluronic acid, laminin, type IV collagen) and liver function indexes (ALT, total bilirubin) in entecavir and enalapril treatment groups decreased significantly and albumin levels increased significantly Compared with before treatment and control group, the difference was statistically significant (P <0.05). There was no significant difference in HBV-DNA negative rates between the two groups at 3 and 6 months of treatment (P> 0.05). Conclusion: The effect of ligonavir combined with entecavir on the recovery of liver function and the decrease of serum liver fibrosis index in patients with chronic hepatitis B is better than that of entecavir alone, but there is no statistical difference between the two methods in decreasing the level of chronic hepatitis B virus Significance (P> 0.05).