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CpGODN是包含未甲基化的CpG基序的寡核苷酸,可以通过识别Toll样受体9(TLR9)诱导浆细胞样树突状细胞(PDC),促进其在归巢的同时由未成熟状态向成熟状态转化,并有效地提呈抗原,增加共刺激分子的表达,提供T细胞活化需要的第二信号;另外,CpGODN诱导PDC释放细胞因子IFN-α、同时在CD40L的协助下释放IL-12,由此引发T细胞向Th1方向分化和活化NK细胞,释放IFN-γ,启动先天性免疫和获得性免疫。对CpGODN的深入研究,将对抗感染、肿瘤免疫提供新的途径。
CpG ODN is an oligonucleotide that contains an unmethylated CpG motif that induces plasmacytoid dendritic cells (PDC) by recognizing Toll-like receptor 9 (TLR9), promoting its maturation by homing State to the mature state and effectively presented antigens to increase the expression of costimulatory molecules to provide the second signal required for T cell activation; In addition, CpGODN induced PDC release of cytokine IFN-α, while releasing CD with the help of IL -12, triggering T cells to differentiate in Th1 direction and activating NK cells, releasing IFN-γ, initiating innate and adaptive immunity. In-depth study of CpGODN will provide a new way to combat infection and tumor immunity.