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利用条件性位置偏爱实验研究钙拮抗剂粉防己碱对小鼠吗啡奖赏效应的影响 .实验采用有倾向性程序 .吗啡 ( 5mg· kg-1,sc,每日 1次 ,5d)引起小鼠显著的位置偏爱效应 .在训练阶段每天 sc吗啡前 30 min预先给予粉防己碱 ( 1 0 ,2 0和 40 mg·kg-1,ip)可剂量依赖性地抑制吗啡引起的小鼠位置偏爱效应 .而粉防己碱 ( 1 0 ,2 0和 40 mg· kg-1,ip)只在测试前 30 min给药 1次 ,不影响吗啡已形成的小鼠位置偏爱 .结果说明粉防己碱能有效地抑制吗啡偏爱效应的获得 ,但不影响其表达 .
The conditioned place preference test was used to study the effect of calcium antagonist tetrandrine on morphine reward effect in mice.Patients were induced by morphine (5 mg · kg -1, sc once a day for 5 days) (10, 20, and 40 mg · kg-1, ip) in the training phase 30 min before sc morphine dose-dependently inhibited the morphine-induced mouse position-favoring effect. Tetrandrine (10, 20 and 40 mg · kg-1, ip) was given only once 30 min before the test, which did not affect the morphine-induced mouse position preference. The results showed that tetrandrine can effectively Inhibition of morphine preference effect, but does not affect its expression.