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目的:探讨监测脑钠肽(BNP)对判断老年感染性休克患者预后的临床意义。方法:回顾性分析78例于2007年6月至2013年10月入住的老年感染性休克患者的临床资料,根据其入科6及24 h BNP水平,分为A组(BNP<100 pg/mL)、B组(100 pg/mL≤BNP<500 pg/mL)和C组(BNP≥500 pg/mL)。比较各组24 h内APACHE II评分、6、24 h血乳酸值,ICU住院时间及患者入ICU后28 d内死亡率。结果:A组和B组APACHEⅡ评分、血乳酸及ICU住院时间,28 d内死亡率比较,差异无统计学意义(P>0.05),与A组、B组比较,C组上述指标均显著升高(P<0.05)。结论:BNP水平对老年感染性休克患者预后的判断有一定意义,BNP水平≥500 pg/mL可能是患者病情加重及死亡率增高的一个重要判断指标。
Objective: To investigate the clinical significance of monitoring brain natriuretic peptide (BNP) in judging the prognosis of septic shock in elderly patients. Methods: The clinical data of 78 elderly patients with septic shock admitted from June 2007 to October 2013 were retrospectively analyzed. Group A (BNP <100 pg / mL ), Group B (100 pg / mL≤BNP <500 pg / mL) and group C (BNP≥500 pg / mL). The APACHE II score within 24 h, the blood lactate value of 6 and 24 h, the hospital stay of ICU and the intra-ICU mortality within 28 days were compared between groups. Results: There was no significant difference in APACHEⅡscore, blood lactic acid, ICU hospitalization time and mortality within 28 days in group A and group B (P> 0.05). Compared with group A and group B, the above indexes in group C were significantly increased High (P <0.05). Conclusions: The level of BNP has some significance in judging the prognosis of septic shock in elderly patients. BNP level ≥ 500 pg / mL may be an important diagnostic indicator for the patients’ exacerbation and mortality.