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目的：观察博宁单独使用与博宁联合化疗对实体瘤骨转移引起疼痛的疗效。方法：对４４ 例实体瘤骨转移患者随机分为治疗组（ 博宁单独应用） 与对照组（ 博宁联合化疗） 静脉滴注博宁９０ｍ ｇ ，２ 至４ 周重复，对照组于次日行常规方案化疗（２ 周期） 。结果：治疗组１８ 例，显效８ 例，有效６ 例，无效４ 例，总有效率７７ ．８ ％ （１４／１８） ，一周内取得疗效占５０ ％ （９／１８） ，毒副反应２ 例占１１ ．１ ％ （２／１８） 。对照组２６ 例，显效１２ 例，有效１１ 例，无效３ 例，总有效率８８ ．５ ％ （２３／２６） ，一周内取得疗效占５７ ．７ ％ （１５／２６） ，毒副反应４ 例占１５ ．４ ％ （４／２６） 。结论：博宁单独使用与博宁联合化疗治疗骨转移的疼痛均具有良好的止痛效果。
OBJECTIVE: To observe the effect of Bonin alone and Bonin combined with chemotherapy on bone metastases caused by solid tumors. Methods: Forty-four patients with solid tumor bone metastases were randomly divided into treatment group (Berning alone) and control group (Borning combined with chemotherapy) intravenously infusion of 90 ng of Bonin for 2 to 4 weeks. The control group was performed on the next day. Conventional regimen chemotherapy (2 cycles). Results: In the treatment group 18 cases, 8 cases were markedly effective, 6 cases were effective, 4 cases were ineffective, and the total effective rate was 77. 8 % (14/18) achieved a therapeutic effect of 50% (9/18) within one week, and 2 of toxic adverse reactions accounted for 11. 1 % (2/18). In the control group, 26 cases were markedly effective in 12 cases, effective in 11 cases, and invalid in 3 cases. The total effective rate was 88. 5 % (23/26) achieved curative effect within a week of 57. 7 % (15/26), toxic adverse reactions in 4 cases accounted for 15. 4 % (4/26). Conclusion: Bonin alone and Bonin combined with chemotherapy for bone metastasis have good analgesic effect.