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截短侧耳类抗菌药物泰妙菌素和沃尼妙林是兽医专用药。随着病原菌对现有药物的耐药性在全球范围蔓延,现在兴起了开发新的截短侧耳衍生物用于治疗人类细菌感染。瑞他帕林(Rapamulin)是第一个用于人医的截短侧耳类药物,2007年被批准用于由金黄色葡萄球菌(Staphylococcus aureus)和酿脓葡萄球菌(Staphylococcus pyogenes)引起的皮肤感染。截短侧耳衍生物在人医上的开发应用使其耐药机制成为国际上的研究热点。本文就截短侧耳类药物耐药机制及其传播机理的研究进展进行综述。
Truncated lateral ear antibacterials Tiamulin and Wane Miao Lin is a veterinary medicine. With the spread of pathogenic resistance to existing agents worldwide, the development of new truncated Pleurotus ostreatus is emerging to treat human bacterial infections. Rapamulin, the first truncated pleuriser for human medicine, was approved in 2007 for skin infections caused by Staphylococcus aureus and Staphylococcus pyogenes . The development and application of truncated Pleurotus ostreatus in human medicine make its resistance mechanism become an international research hotspot. This review summarizes the progress of research on the mechanism of drug resistance in truncated Pleurotus ostreatus and its transmission mechanism.