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目的研究乐胃煎逆转胃癌前病变不完全结肠型肠化和／或中度异型增生的疗效．方法胃镜病理证实为不完全结肠型肠化和／或中度异型增生４６例．治疗组３０例用乐胃煎，对照组１６例用德诺（Ｄｅ＿Ｎｏｌ）．治疗前后胃镜活检胃窦固定部位粘膜标本作ＡｇＮＯＲ染色及细胞图像分析．结果乐胃煎对不完全结肠型肠化及中度异型增生总有效率均高于Ｄｅ＿Ｎｏｌ，分别为７２％比２５％（Ｐ＜００５）和８９５％比４４４％（Ｐ＜００５）．乐胃煎治疗前后，ＡｇＮＯＲ计数分别为７３０±１１６和４８１±１５０（Ｐ＜００１），Ｄｅ＿Ｎｏｌ组为７７３±０９２和７０５±１０２（Ｐ＜００１）．两组治疗前后ＡｇＮＯＲ计数差值均数相比，统计学上也有显著性差异，分别为２５２±１５４和０６９±０４８（Ｐ＜００１）．乐胃煎组中２０例作细胞图像分析，治疗后各参数（长轴、短轴、核浆比、结构异型指数等）均有不同程度的降低，有显著性差异．结论乐胃煎确有较好地逆转胃癌前病变的功效．
1. Objective To study the therapeutic effect of Lewei decoction on reversing incomplete colonic intestinal metaplasia and/or moderate dysplasia. Methods Endoscopic pathology confirmed 46 cases of incomplete colonic intestinal metaplasia and/or moderate dysplasia. In the treatment group, 30 cases were treated with Lewei Jian, and in the control group, 16 cases were treated with De Nol. Before and after treatment, gastroscopy biopsy mucosal specimens of the gastric antrum for AgNOR staining and cell image analysis. Results The total effective rate of Le stomach decoction on incomplete colonic intestinal metaplasia and moderate dysplasia was higher than that of De_Nol, 72% vs 25% (P<005) and 895% vs 444% (P). <005). Before and after Le stomach decoction treatment, AgNOR counts were 730±116 and 481±150, respectively (P<001), and DeDeNol group was 773±092 and 705±1. 02(P<001). Differences in the mean difference in counts of AgNOR between the two groups before and after treatment were also statistically significant (252±154 and 069±048, respectively) (P<001). In the Lewei Jian group, 20 cases were used for cell image analysis. After treatment, each parameter (long axis, short axis, nuclear-to-plasma ratio, structural heterotypic index, etc.) decreased to varying degrees, with significant differences. Conclusion Le stomach decoction can effectively reverse the effect of precancerous lesions.