新生儿呼吸窘迫综合征是早产儿常见病 ,病死率占早产儿之首 ,严重威胁着新生儿的健康。病因主要是肺泡表面缺乏表面活性物质。L iggins首先发现糖皮质激素有促进了肺泡表面活性物质形成的作用。到目前为止 ,糖皮质激素类药物已被各国广泛应用于促胎肺成熟领域 ,成功的降低了新生儿发病率、死亡比。 Neonatal respiratory distress syndrome is a common disease in preterm children, the mortality rate accounted for the first premature children, a serious threat to the health of newborns. The main cause of the lack of surface alveolar surfactant. L iggins first found that glucocorticoids have contributed to the formation of alveolar surfactant. So far, glucocorticoid drugs have been widely used in various countries to promote fetal lung maturation, successfully reducing the morbidity and mortality of neonates.