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目的肾上腺皮质激素联用白三烯受体拮抗剂孟鲁司特钠治疗儿童哮喘急性发作中的临床效果,提供哮喘防治新途径。方法于哮喘发作时,在使用肾上腺皮质激素、β2受体激动剂氧驱雾化吸入的基础上联用孟鲁司特钠4mg/次,1次/日,睡前服,并配合抗生素抗炎,平喘、化痰综合治疗。结果治疗组总有效率92%,对照组总有效率68%,两组总有效率比较治疗组优于对照组,差异有统计学意义(χ2=4.06,P<0.05)。结论白三烯受体拮抗剂可使哮喘缓解加速,在延缓哮喘气道重塑发生过程中起重要作用,治疗儿童哮喘急性发作效果显著,使用安全、简便、无不良反应。
Objective To investigate the clinical effect of montelukast sodium in combination with leukotriene receptor antagonist sodium on the treatment of acute asthma in children and to provide a new way of asthma control. Methods In the asthma attack, the use of adrenocorticotropic hormone, β2 receptor agonist oxygen inhalation based on the combination of montelukast sodium 4mg / time, 1 / day, before going to bed, and with antibiotics, anti-inflammatory , Asthma, phlegm comprehensive treatment. Results The total effective rate was 92% in the treatment group and 68% in the control group. The total effective rate in the two groups was better than that in the control group (χ2 = 4.06, P <0.05). Conclusion Leukotriene receptor antagonists can accelerate the remission of asthma and play an important role in delaying the process of asthma airway remodeling. The treatment of acute asthma in children is effective, safe, simple and without adverse reactions.