高血脂症是一种常见的代谢性疾病,是引起心脑血管疾病的重要危险因素。胆固醇假说进一步认为LDL-C是导致动脉粥样硬化心血管疾病的主要原因,降低LDL-C水平即可降低心血管事件的发生率。本文综述他汀类药物、胆固醇吸收抑制剂及枯草溶菌素转化酶9抑制剂等以胆固醇假说为核心的降脂药物的研究进展,旨在为降脂药物的临床应用提供理论指导。 Hyperlipidemia is a common metabolic disease, which is an important risk factor for cardiovascular and cerebrovascular diseases. Cholesterol hypothesis further that LDL-C is the leading cause of atherosclerotic cardiovascular disease, reduce the level of LDL-C can reduce the incidence of cardiovascular events. This review summarizes the progress of lipid-lowering drugs with cholesterol hypocotyl as the core, such as statins, cholesterol absorption inhibitors and subtilisin-9 inhibitors, so as to provide theoretical guidance for the clinical application of lipid-lowering drugs.