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目的:研究育阴软肝方对复合因素致亚急性肝纤维化小鼠的作用。方法:采用ig CCl4并饮用15%乙醇来复制肝纤维化小鼠模型,通过HE染色观测肝组织纤维病理变化,测定大鼠肝脏指数、肝组织羟脯氨酸含量以及血清肝功能指标,研究育阴软肝方对实验性肝纤维化的保护作用。结果:9g/kg～36g/kg剂量范围内的育阴软肝方能促进大鼠体重增长,降低肝脏指数、肝组织羟脯氨酸与胶原蛋白的含量以及血清肝功能指标(ALT、AST),改善肝纤维化模型动物肝组织病理变化。结论:育阴软肝方具有一定的抗肝纤维化作用。
Objective: To study the effect of Yuyin Rougan Decoction on sub-acute liver fibrosis induced by multiple factors in mice. Methods: Liver fibrosis was induced by using ig CCl4 and drinking 15% ethanol. The pathological changes of liver fibrosis were observed by HE staining. The liver index, hydroxyproline content in liver tissue and serum liver function were measured. Protective Effects of Yin Rougan Recipe on Experimental Hepatic Fibrosis. Results: Yuyin Rougan Decoction could improve body weight gain, reduce liver index, content of hydroxyproline and collagen in liver tissue and serum liver function index (ALT, AST) in the range of 9g / kg ~ 36g / , Improve hepatic fibrosis liver tissue pathological changes. Conclusion: YYR has certain anti-hepatic fibrosis effect.