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目的比较肝细胞癌、肝硬化和结节状增生中血管内皮细胞标记物CD34 、UEA -Ⅰ和Ⅷ因子的表达及意义。 方法对 36例手术切除肝细胞癌 ,其中 19例癌旁肝硬化、4例结节状增生及 2例正常肝组织进行免疫组织化学标记。 结果 1.CD34 在所有肝细胞癌 (HCC)血窦中均有较强阳性的表达 ,肝硬化 ,结节状增生及正常肝组织血窦中仅 3例有弱阳性的CD34 表达 ;2 .UEA -Ⅰ在HCC、肝硬化及结节状增生中均有较强阳性的血窦表达。CD34 在HCC血窦中表达与肝硬化、结节状增生相比显著增强 (P <0 .0 1) ;UEA -Ⅰ在HCC和肝硬化、结节状增生血窦表达无显著差异 (P >0 .0 5 )。 结论HCC与肝硬化、结节状增生血窦CD34 表达的差异可能与肿瘤的血管形成有关 ,而非简单的毛细血管化 ;CD34 可作为区别高分化HCC与非肿瘤病变的辅助指标
Objective To compare the expressions of CD34, UEA-I and factor Ⅷ in hepatocellular carcinoma, cirrhosis and nodular hyperplasia. Methods Totally 36 cases of HCC were excised, including 19 cases of adjacent cirrhosis, 4 cases of nodular hyperplasia and 2 cases of normal liver tissue. Immunohistochemical staining was performed. CD34 expression was strongly positive in all sinusoids of HCC (cirrhosis, nodular hyperplasia and normal liver tissue), and only 3 of them had weakly positive CD34 expression.2. -I in HCC, cirrhosis and nodular hyperplasia have strong positive sinusoidal expression. The expression of CD34 in HCC sinusoid was significantly higher than that in cirrhosis and nodular hyperplasia (P <0.01). There was no significant difference in the expression of CD34 between UEA-Ⅰ and HCC in cirrhosis and nodular hyperplasia (P> 0 .0 5). Conclusions The difference of CD34 expression between HCC and cirrhosis and nodular hyperplasia may be related to tumor angiogenesis rather than simple capillary angiogenesis. CD34 can be used as an auxiliary index to differentiate well-differentiated HCC from non-neoplastic lesions